منابع مشابه
Fosfomycin for the initial treatment of acute haematogenous osteomyelitis.
BACKGROUND AND AIMS At our institution there has been a dichotomous antimicrobial treatment behaviour for acute haematogenous osteomyelitis (AHOM) since 1984. The surgical department favoured fosfomycin as initial choice and the medical department beta lactams. We aimed to compare the performance of both strategies. METHODS Data from patients discharged with the diagnosis of AHOM between Janu...
متن کاملFosfomycin: A First-Line Oral Therapy for Acute Uncomplicated Cystitis
Fosfomycin is a new agent to Canada approved for the treatment of acute uncomplicated cystitis (AUC) in adult women infected with susceptible isolates of E. coli and Enterococcus faecalis. We reviewed the literature regarding the use of oral fosfomycin for the treatment of AUC. All English-language references from 1975 to October 2015 were reviewed. In Canada, fosfomycin tromethamine is manufac...
متن کاملIn vitro activity of fosfomycin-gentamicin, fosfomycin-ceftazidime, fosfomycin-imipenem and ceftazidime-gentamicin combinations against ceftazidime-resistant Pseudomonas aeruginosa.
The effects of antimicrobial combinations against ceftazidime-resistant Pseudomonas aeruginosa strains isolated from hospitalized patients were investigated. Using the checkerboard titration method, combination of fosfomycin-gentamicin, fosfomycin-ceftazidime, fosfomycin-imipenem and ceftazidime-gentamicin was synergistic against 4, 11, 38 and 39% of 22, 18, 29 and 18 strains tested respectivel...
متن کاملTransposon Encoding Fosfomycin Resistance
The determinant of resistance to fosfomycin of the Serratia marcescens plasmid pOU900 was transposed into the plasmid ColEl and into the plasmid RP4 in the absence of the RecA function of the host. In each case, the acquisition of fosfomycin resistance was correlated with the presence of a discrete piece of DNA, uniform in size and in restriction pattern. This new, 7.5-megadalton transposable e...
متن کاملFosfomycin monophosphate and fosfomycin diphosphate, two inactivated fosfomycin derivatives formed by gene products of fomA and fomB from a fosfomycin producing organism Streptomyces wedmorensis.
Fig. 1. Structures of FMand FMderivatives inactivated by gene products offomA andfomB. analysis revealed the presence of six open reading frames with unknownfunctions in the sequenced fragment, in addition to the four genes necessary to FMbiosynthesis. So far studied, most antibiotic-producing Streptomyces possessed resistance genes and regulatory genes in their antibiotic production gene clust...
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ژورنال
عنوان ژورنال: Chemotherapy
سال: 1977
ISSN: 0009-3157,1421-9794
DOI: 10.1159/000222073